Supplement 101

Supplement Is Not a Drug

Dietary supplements and drugs are regulated differently, with supplements positioned as food-like products that are not evaluated for effectiveness before market.

FDARegulationBasics

Supplements and drugs are defined by different standards.

They may look similar in form — capsules, tablets, powders —
but they are evaluated under fundamentally different regulatory frameworks.

The distinction is structural.

At a high level, the difference comes down to three signals:

  • Intended use — drugs are intended to diagnose, treat, or prevent disease; supplements are intended to support the diet
  • Pre-market evaluation — drugs require approval based on evidence of safety and effectiveness; supplements generally do not
  • Regulatory burden — drug development involves controlled trials and formal review; supplements are governed by manufacturing and labeling rules

This creates two very different systems.

Drugs are evaluated before they are sold.
Supplements are monitored after they are sold.